THE PET PHARMACY By Wendy C. Brooks, DVM, DipABVP Educational Director, VeterinaryPartner.com

(for veterinary information only)

Numerous herbal brands are available (usually as seed extract).

Veterinary brands include: Marin (which combines silymarin with vitamin E and phosphatidyl choline) and Denamarin (which combines silymarin with SAMe)

Background

Milk thistle is a flower, specifically a member of the aster family. Its seeds and roots have been used for an assortment of medical purposes for thousands of years. Three biochemicals of interest have been isolated from the milk thistle: silychristine, silydianin, and silybin, which is also called silybinin and is considered the most powerful of them all. The mixture of these three substances is called silymarin. Silymarin has been traditionally used to treat liver disease and while it has recently been advocated for use in pets, most scientific information available concerns human use. The biological mechanism of action is yet unknown but several theories exist:

• Silymarin may control cell membrane permeability, which means that silymarin may control what substances enter the interior of a cell.
• Silymarin may inhibit chemical pathways leading to inflammatory biochemicals.
• Silymarin may have free radical scavenging properties, which means that it may absorb harmful reactive atoms that could damage other molecules.
• Silymarin may increase protein production by liver cells.
• Silymarin may stabilize mast cells (cells containing inflammatory granules.
• Silymarin in high doses increases the flow of bile.

How this Medication is Used

In human patients with cirrhotic livers, silymarin has been shown to improve survival though it has had no effect on liver disease from Hepatitis C or in alcohol-induced hepatitis. This means silymarin may not be helpful for all liver diseases although it is a safe substance and should not cause problems if used in a liver condition where its benefit is unproven. In dogs and cats, silymarin has been shown to be helpful in cases of amanita mushroom toxicity and it was protective after carbon tetrachloride administration (both are situations are toxic liver diseases).

Side Effects

At doses greater than 1.5 grams per day the increased bile flow side effect may cause diarrhea. Side effects are rare but the following has been reported for humans: upset stomach, headache, joint pain, weakness.

Interactions with other Drugs

While there are no known drug interactions, it is important to remember that herbal medications are not held to the same standards of efficacy and safety that other drugs are. Impurities in processing may include less innocuous plant biochemicals.

Concerns and Cautions

Silymarin is not recommended for humans during pregnancy. It is probably a good idea not to use milk thistle products in pregnant dogs until more information becomes available.

Milk thistle products should be stored at room temperature.

Because herbal medications are not held to the same purity and efficacy standards
as other medications, there may tremendous variation in strength between brands or even between batches of the same brand.

We recommend checking with your veterinarian about what brand he or she feels is reliable.

Date Published: 12/6/2004 11:29:00 AM
Date Reviewed/Revised: 09/21/2008